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  1. Casula, A., Llopis-Lorente, A., Garau, A., Isaia, F., Kubicki, M., Lippolis, V., Sancenón, F., Martínez-Máñez, R., Owczarzak, A., Santi, C.,  Scorciapino M.A., Caltagirone, C A New class of silica-supported chromo-fluorogenic chemosensors for anion recognition based on a selenourea scaffold (2017) Chem. Commun.,53, 3729-3732 .DOI: 10.1039/C7CC01214D
  2. Perin, G; Barcellos, AM; Luz, EQ ; Borges, EL; Jacob, RG; Lenardao, EJ; Sancineto, L; Santi, C  Green Hydroselenation of Aryl Alkynes: Divinyl Selenides as a Precursor of Resveratrol (2017) Molecules 22 (2), 327. DOI: 10.3390/molecules2202032
  3. Fiorito, S., Epifano, F., Preziuso, F., Taddeo, V.A., Santi, C., Genovese, S. New insights into the seleniranium ion promoted cyclization of prenyl and propenylbenzene aryl ethers (2017) Tetrahedron Letters, 58 (4), pp. 371-374. DOI: 10.1016/j.tetlet.2016.12.044
  4. Barcellos, A.M., Abenante, L., Sarro, M.T., Di Leo, I., Lenardão, E.J., Perin, G., Santi, C. New Prospective for Redox Modulation mediated by Organoselenium and Organotellurium Compounds (2017) Curr. Org. Chem. 21, In press 10.2174/1385272820666161020162113 ocietà Editrice Esculapio, rsm unsaturated acids into butenolides
  5. Tomassini, C., Di Sarra, F.,Monti, B., Sancineto, L., Bagnoli, L., Marini, F., Santi, C. Kinetic resolution of 2-methoxycarbonylalk-3-enols through a stereoselective cyclofunctionalization promoted by an enantiomerically pure electrophilic selenium reagent (2017) Arkivoc, part. Ii, 303-312 DOI: 10.3998/ark.5550190.p009.826
  6. Santi, C., Jacob, R.G., Monti, B ., Bagnoli, L., Sancineto, L., Lenardão E.J. Water and Aqueous Mixtures as Convenient Alternative Media for Organoselenium Chemistry (2016) Molecules 21 (11), 1482 DOI: 10.3390/molecules21111482
  7. Perin, G., Barcellos, A.M., Peglow, T.J., Nobre, P.C., Cargnelutti, R., Lenardão, E.J., Marini, G., Santi, C. Tellurium-promoted stereoselective hydrodebromination of 1, 1-dibromoalkenes: synthesis of (E)-bromoalkenes (2016) RSC Advances 6 (105), 103657-103661. DOI: 10.1039/C6RA24295B
  8. Luz, E.Q., Lopes, E.F., Ricordi, V.G., Santi, C., Barcellos, T., Lenardão, E.J., Perin, G., Alves, D. Water‐Dependent Selective Synthesis of Mono‐or Bis‐Selanyl Alkenes from Terminal Alkynes (2016) ChemistrySelect 1 (14), 4289-4294 DOI 10.1002/slct.201601177 
  9. Palomba, M., Vinti, E., Marini, F., Santi, C., Bagnoli, L. Synthesis of oxazino[4,3-a]indoles by domino addition-cyclization reactions of (1H-indol-2-yl)methanols and vinyl selenones in the presence of 18-crown-6. (2016) Tetrahedron, 72 (44), pp. 7059-7064. DOI: 10.1016/j.tet.2016.09.045
  10. Sancineto, L., Piccioni, M., De Marco, S., Pagiotti, R., Nascimento, V., Braga, A.L., Santi, C., Pietrella, D. Diphenyl diselenide derivatives inhibit microbial biofilm formation involved in wound infection (2016) BMC Microbiology, 16 (1), art. no. 220. DOI: 10.1186/s12866-016-0837-x
  11. Soufiane El Houssame, Boualy brahim, luca sancineto, Claudio Santi, Mustapha AIT ALI, Larbi El Firdoussi and Helen Stoeckli-Evans  A mild and efficient method for the synthesis of a new optically active diallyl selenide and its catalytic activity in allylic chlorination of natural terpenes,  New J. Chem., 2016DOI: 10.1039/C5NJ02797G
  12. Amber N Hancock Greener Approaches to Radical Reactions Involving Chalcogens: From Homolytic Substitution to Photocleavage 2016Curr. Green Chem. DOI: 10.2174/2213346103666160127004235
  13. Thomas G BackOxidations Catalyzed by Seleninic Acids and Anhydrides, their Precursors and Congener2016Curr. Green Chem. DOI: 10.2174/2213346103666160127003954
  14. Bonifacio Monti, Claudio Santi, Luana Bagnoli, Francesca Marini and Luca Sancineto Zinc Chalcogenolates as Green Reagents 2016Curr. Green Chem. DOI: 10.2174/2213346103666160127003716

    Juliano B. Azeredo, Ricardo S. Schwab and Antonio L Braga.Synthesis of Biologically Active Selenium-Containing Molecules from Greener Perspectives 2016Curr. Green Chem.DOI: 10.2174/2213346103666160127003506
  16. Agata Joanna Pacula and Jacek Scianowski. Terpenes as Green Starting Materials for New Organoselenium and Organotellurium Compounds 2016Curr. Green Chem. DOI: 10.2174/2213346103666160127003257

    Barahman Movassagh and Elmira MohammadiGreen Trends in Synthesis of Alkenyl and Alkynyl Chalcogenides 2016Curr. Green Chem.   DOI: 10.2174/2213346103666160127003122
  18. Eder J. Lenardao, Liane K. Soares, Angelita M. Barcellos and Gelson Perin. KF/Al2O3 as a Green System for the Synthesis of Organochalcogen Compounds  2016Curr. Green Chem. DOI: 10.2174/2213346103666160127002811
  19. Agata J. Pacula, Francesca Mangiavacchi, Luca Sancineto, Eder J. Lenardao, Jacek Scianowskiand Claudio SantiAn Update on “Selenium Containing Compounds from Poison to Drug Candidates: A review on the GPx-like Activity” Curr. Chem. Biol., 2016DOI: 10.2174/2212796810666160120220
  20. M. Palomba,   L. Rossi,   L. Sancineto,   E. Tramontano,  A. Corona,   L. Bagnoli,   C. Santi,   C. Pannecouque,  O. Tabarrinia and   F. Marini A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity. Org. Biomol. Chem., 2016,14, 2015-2024. DOI: 10.1039/C5OB02451J


Palomba, M., Bagnoli, L., Marini, F., Santi, C., Sancineto, L.


Recent advances in the chemistry of vinylchalcogenides


(2016) Phosphorus, Sulfur and Silicon and the Related Elements, 191 (2), pp. 235-244.


DOI: 10.1080/10426507.2015.1067212




105. Sancineto, L., Palomba, M., Bagnoli, L., Marini, F., Santi, C.


Advances in electrophilic organochalcogen reagents


(2016) Current Organic Chemistry, 20 (2), pp. 122-135.


DOI: 10.2174/1385272819666150724233204




104. Palomba, M., Rossi, L., Sancineto, L., Tramontano, E., Corona, A., Bagnoli, L., Santi, C., Pannecouque, C., Tabarrini, O., Marini, F.


A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity


(2016) Organic and Biomolecular Chemistry, 14 (6), pp. 2015-2024.


DOI: 10.1039/c5ob02451j




103. Sancineto, L., Tidei, C., Bagnoli, L., Marini, F., Lippolis, V., Arca, M., Lenardão, E.J., Santi, C.


Synthesis of Thiol Esters Using PhSZnBr as Sulfenylating Agent: A DFT-Guided Optimization of Reaction Conditions


(2016) European Journal of Organic Chemistry, 2016 (17), pp. 2999-3005.


DOI: 10.1002/ejoc.201600366




102. Bellino, G., Scisciani, M., Vargas, J.P., Sancineto, L., Bagnoli, L., Marini, F., Lüdtke, D.S., Lenardao, E.J., Santi, C. Reaction of Acyl Chlorides with in Situ Formed Zinc Selenolates: Synthesis of Selenoesters versus Ring-Opening Reaction of Tetrahydrofuran


(2016) Journal of Chemistry, 2016, art. no. 2849140.


DOI: 10.1155/2016/2849140




101. Sancineto, L., Mariotti, A., Bagnoli, L., Marini, F., Desantis, J., Iraci, N., Santi, C., Pannecouque, C., Tabarrini, O. Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity


(2015) Journal of Medicinal Chemistry, 58 (24), pp. 9601-9614.


DOI: 10.1021/acs.jmedchem.5b01183




100. Lopes, E.F., Gonçalves, L.C., Vinueza, J.C.G., Jacob, R.G., Perin, G., Santi, C., Lenardão, E.J.


DES as a green solvent to prepare 1,2-bis-organylseleno alkenes. Scope and limitations


(2015) Tetrahedron Letters, 56 (49), pp. 6890-6895.


DOI: 10.1016/j.tetlet.2015.10.095




99. Sancineto, L., Tidei, C., Bagnoli, L., Marini, F., Lenardão, E.J., Santi, C.


Selenium catalyzed oxidation of aldehydes: Green synthesis of carboxylic acids and esters


(2015) Molecules, 20 (6), pp. 10496-10510.


DOI: 10.3390/molecules200610496




98. Vieira, B.M., Thurow, S., Brito, J.S., Perin, G., Alves, D., Jacob, R.G., Santi, C., Lenardão, E.J.


Sonochemistry: An efficient alternative to the synthesis of 3-selanylindoles using CuI as catalyst


(2015) Ultrasonics Sonochemistry, 27, pp. 192-199.


DOI: 10.1016/j.ultsonch.2015.05.012




97. Vieira, A.A., Azeredo, J.B., Godoi, M., Santi, C., Da Silva Júnior, E.N., Braga, A.L.


Catalytic chalcogenylation under greener conditions: A solvent-free sulfur- and seleno-functionalization of olefins via I2/DMSO oxidant system


(2015) Journal of Organic Chemistry, 80 (4), pp. 2120-2127.


DOI: 10.1021/jo502621a




96. Ciancaleoni, G., Santi, C., Ragni, M., Braga, A.L.


Charge-displacement analysis as a tool to study chalcogen bonded adducts and predict their association constants in solution


(2015) Dalton Transactions, 44 (46), pp. 20168-20175.


DOI: 10.1039/c5dt03388h




95. Achibat, H., AlOmari, N.A., Messina, F., Sancineto, L., Khouili, M., Santi, C.


Organoselenium compounds as phytochemicals from the natural Kingdom


(2015) Natural Product Communications, 10 (11), pp. 1885-1892.






94. Pacuła, A.J., Mangiavacchi, F., Sancineto, L., Lenardão, E.J., Ścianowski, J., Santi, C.


An update on “selenium containing compounds from poison to drug candidates: A review on the GPx-like activity”


(2015) Current Chemical Biology, 9 (2), pp. 97-112.


DOI: 10.2174/2212796810666160120220725




93. Bartolini, D., Commodi, J., Piroddi, M., Incipini, L., Sancineto, L., Santi, C., Galli, F.


Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides


(2015) Free Radical Biology and Medicine, 88 (Part B), pp. 466-480.


DOI: 10.1016/j.freeradbiomed.2015.06.039






91. Bartolini, D., Piroddi, M., Tidei, C., Giovagnoli, S., Pietrella, D., Manevich, Y., Tew, K.D., Giustarini, D., Rossi, R., Townsend, D.M., Santi, C., Galli, F.


Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its d,l-polylactide microparticle formulation


(2015) Free Radical Biology and Medicine, 78, pp. 56-65.


DOI: 10.1016/j.freeradbiomed.2014.10.008




88. Giovagnoli, S., Marenzoni, M.L., Nocchetti, M., Santi, C., Blasi, P., Schoubben, A., Ricci, M.


Synthesis, characterization and in vitro extracellular and intracellular activity against Mycobacterium tuberculosis infection of new second-line antitubercular drug-palladium complexes


(2014) Journal of Pharmacy and Pharmacology, 66 (1), pp. 106-121.


DOI: 10.1111/jphp.12162




87. Santoro, S., Azeredo, J.B., Nascimento, V., Sancineto, L., Braga, A.L., Santi, C.


The green side of the moon: Ecofriendly aspects of organoselenium chemistry


(2014) RSC Advances, 4 (60), pp. 31521-31535..


DOI: 10.1039/c4ra04493b




86. Tidei, C., Sancineto, L., Bagnoli, L., Battistelli, B., Marini, F., Santi, C.


A recyclable biphasic system for stereoselective and easily handled hydrochalcogenations


(2014) European Journal of Organic Chemistry, 2014 (27), pp. 5968-5975.


DOI: 10.1002/ejoc.201402668




85. Nascimento, V., Ferreira, N.L., Canto, R.F.S., Schott, K.L., Waczuk, E.P., Sancineto, L., Santi, C., Rocha, J.B.T., Braga, A.L.


Synthesis and biological evaluation of new nitrogen-containing diselenides


(2014) European Journal of Medicinal Chemistry, 87, pp. 131-139.


DOI: 10.1016/j.ejmech.2014.09.022




80. Sternativo, S., Battistelli, B., Bagnoli, L., Santi, C., Testaferri, L., Marini, F.


Synthesis of γ-lactams via a domino Michael addition/cyclization reaction of vinyl selenone with substituted amides


(2013) Tetrahedron Letters, 54 (49), pp. 6755-6757.


DOI: 10.1016/j.tetlet.2013.10.004




79. Propersi, S., Tidei, C., Bagnoli, L., Marini, F., Testaferri, L., Santi, C.


" On-water " thiolysis of epoxides promoted by PhSZnBr


(2013) Journal of Sulfur Chemistry, 34 (6), pp. 671-676.


DOI: 10.1080/17415993.2013.781604






77. Santi, C., Tidei, C., Scalera, C., Piroddi, M., Galli, F.


Selenium containing compounds from poison to drug candidates: A review on the GPx-like activity


(2013) Current Chemical Biology, 7 (1), pp. 25-36.


DOI: 10.2174/2212796811307010003




76. Santi, C., Galli, F., Piroddi, M., Tidei, C.


Thiols oxidation for the evaluation of Gpx-like activity


(2013) Phosphorus, Sulfur and Silicon and the Related Elements, 188 (4), pp. 507-508.


DOI: 10.1080/10426507.2012.727924




74. Bagnoli, L., Casini, S., Marini, F., Santi, C., Testaferri, L.


Vinyl selenones: Annulation agents for the synthesis of six-membered benzo-1,4-heterocyclic compounds


(2013) Tetrahedron, 69 (2), pp. 481-486.


DOI: 10.1016/j.tet.2012.11.036




73. Santi, C., Di Lorenzo, R., Tidei, C., Bagnoli, L., Wirth, T.


Stereoselective selenium catalyzed dihydroxylation and hydroxymethoxylation of alkenes


(2012) Tetrahedron, 68 (51), pp. 10530-10535.


DOI: 10.1016/j.tet.2012.08.078




72. Santi, C., Battistelli, B., Testaferri, L., Tiecco, M.


On water preparation of phenylselenoesters


(2012) Green Chemistry, 14 (5), pp. 1277-1280.


DOI: 10.1039/c2gc16541d




71. Tidei, C., Piroddi, M., Galli, F., Santi, C.


Oxidation of thiols promoted by PhSeZnCl


(2012) Tetrahedron Letters, 53 (2), pp. 232-234. Cited 35 times.


DOI: 10.1016/j.tetlet.2011.11.025









  1. S.Propersi  , C. Tidei  , L. Sancineto  , L. Bagnoli  , F. Marini  , C. Santi “ PhSZn-halides: new  green thiolates” Electronic Conference of Synthetic Organic Chemistry (ECSOC-17) Published online: 30 October 2013 and CD ROM Edition ISBN: xxxxxxxx MDPI, Basel, Switzerland
  2. S. Sternativo, B. Battistelli, L. Bagnoli, C. Santi, L. Testaferri, F. Marini Synthesis of γ-Lactam via a Domino Michael Addition/Cyclization Reaction of Vinyl Selenone with Substituted Amide Tetrahedron Letters (2013)
  3. D. Bartolini, S. Ciffolilli, M. Piroddi, G. Murdolo, C. Tortoioli, F. Galli "Biochemistry and nutrition of Selenium: from inorganic form to endogenous proteins" in “Organoselenium Chemistry: Between Synthesis an Biochemistry  Ed: C. Santi, Bentham eBooks (2013) accepted In press
  4. C. Tidei, C. Santi, "Selenium and Bio-Logic catalysis: new bioinspired catalytic reaction" in  “Organoselenium Chemistry: Between Synthesis an Biochemistry  Ed: C. Santi, Bentham eBooks (2013) accepted In press
  5. D. Pietrella "Antimicrobial activity of Organoselenium Compounds" in “Organoselenium Chemistry: Between Synthesis an Biochemistry  Ed: C. Santi, Bentham eBooks (2013) accepted In press
  6. F. Marini, L. Bagnoli, S. Sternativo, "Sinthesis of chiral organoselenium compounds by asymmetric catalysis and applications" in “Organoselenium Chemistry: Between Synthesis an Biochemistry  Ed: C. Santi, Bentham eBooks (2013) accepted In press
  7. C. Santi, C. Tidei “Addition reaction for the formation of C-S and C-Se bond” in Comprehensive Organic Synthesis, Elsevier (2013) 2nd Ed. accepted  In press 
  8. “Organoselenium Chemistry: Between Synthesis an Biochemistry  Ed: C. Santi, Bentham eBooks (2013) accepted In press 
  9. C. Santi in the Science of Synthesis vol. 39- (2013) Thieme: 39.18  Product Class 18 Alkaneselenols
  10. C. Santi in the Science of Synthesis vol. 39- (2013) Thieme: 39.19  Product Class Acyclic Alkaneselenolates
  11. C. Santi, C. Tidei, Electrophilic Se/Te reagents: reactivity and their contribution to "Green Chemistry" Patai: Chemistry of Functional Groups series, (Vol.4) The Chemistry of Organic Selenium and tellurium Compounds. (2013) Wiley  DOI:10.1002/9780470682531.pat0720
  12. C. Santi, F. Galli, M. Piroddi, C. Tidei, Thiols Oxidation for the Evaluation of Gpx-Like Activity Phosphorus, Sulfur, and Silicon and the Related Elements, 2013 188 (4), 507-508.
  13. S. Propersi, C. Tidei, L. Bagnoli, F. Marini, L. Testaferri, C. Santi, “On-Water thiolysis of epoxides promoted by PhSZnBr” J. Sulfur. Chem., 2013, DOI:10.1080/17415993. 2013.781604
  14. C. Santi, C. Tidei, C. Scalera “Selenium containing compounds: from poison to drug candidates  (A review on the GPx-like activity)” Curr. Chem. Biol. 2013, 7, 25-36. 
  15. L. El Firdoussi, A.  Mehdi, C. Santi, S. Giovagnoli, M.  Nocchetti, M. At Ali, Colloidal Nickel(0)-carboxymethyl cellulose particles: a Biopolymer-inorganic Catalyst for Hydrogenation of Nitro-aromatics and Carbonyl compounds“ Cat. Commun., 2013, 32, 92-100.
  16. L. Bagnoli, S. Casini, F. Marini, C. Santi, L. Testaferri “Vinyl selenones: annulation agents for the synthesis of 6-membered benzo-1,4-heterocyclic compounds. “ Tetrahedron , 2013, 69,  481-486.
  17. F. Marini, S. Sternativo, "Organocatalytic asymmetric synthesis and use of organoselenium compounds" Synlett 2013; 24(1): 11-19 DOI: 10.1055/s-0032-1317481.
  18. F. Galli, A. Battistoni, R. Gambari, A. Pompella, A. Bragonzi, F. Pilolli, L. Iuliano, M. Piroddi, M.C. Dechecchi, G. Cabrini, "Oxidative stress and Antioxidant therapy in Cystic Fibrosis", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012, 1822, 690-713.
  19. C. Tidei Phenylselenyl Zinc Halides Synlett 2012; 23(19): 2865-2866
    DOI: 10.1055/s-0032-1317475 
  20. Legnaioli, S.; Piroddi, M.; Tidei, C.; Santi, C.; Galli, F. “Targeting the GSTP-dependent control of cell kinases and apoptosis with PhSeZnCl: a new seleno-organic drug” Free Radical Biology and Medicine vol. 53 September 2012. p. S112 DOI: 10.1016/j.freeradbiomed.2012.08.235. 
  21. Legnaioli, S.; Piroddi, M.; Tidei, C.; Santi, C.; Galli, F. “PhSeZnCl: a new seleno-organic compound with glutathione peroxidase-like activity” Free Radical Biology and Medicine vol. 53 September 2012. p. S147 DOI: 10.1016/j.freeradbiomed.2012.08.308
  22. C. Santi, R. Di Lorenzo, C. Tidei, L. Bagnoli, T. Wirth “Stereoselective Selenium catalyzed Dihydroxylation and Hydroxymethoxylation of Alkenes” Tetrahedron (2012), 68, 10530-10535
  23. S. Sternativo, O. Walczak, B. Battistelli, L. Testaferri, F. Marini, "Organocatalytic Michael addition of indanone carboxylates to vinyl selenone for the asymmetric synthesis of polycyclic pyrrolidines"Tetrahedron (2012), 68, 10536-1054.
  24. L. Di Schino, F. Mangiavacchi, A. Antoszewska, J. Scianowski and C. Santi “Eco-Friendly Selenium Catalyzed Oxidative Cyclizations” Electronic Conference of Synthetic Organic Chemistry (ECSOC-16) Published online: 30 October 2012 and CD ROM Edition ISBN: 3-906980-26-X MDPI, Basel, Switzerland.
  25. L. Incipini, E. Rongoni, L. Bagnoli, F. Marini and C. Santi  “New chiral electrophilic selenium reagents: synthesis and structural investigation” Electronic Conference of Synthetic Organic Chemistry (ECSOC-16) Published online: 30 October 2012 and CD ROM Edition ISBN: 3-906980-26-X MDPI, Basel, Switzerland
  26. C. Tidei, V. Saccomandi, L. Bagnoli, F. Marini and  C. Santi* “Green Oxidations of Aldehydes to Carboxylic Acids and Esters” Electronic Conference of Synthetic Organic Chemistry (ECSOC-16) Published online: 30 October 2012 and CD ROM Edition ISBN: 3-906980-26-X MDPI, Basel, Switzerland
  27. C. Santi, B. Battistelli, L. Testaferri, M. Tiecco “On-Water preparation of phenylselenoesters” Green Chem. 2012, 14, 1277-1280.15. C. Tidei, F. Piroddi, F. Galli, C. Santi “Oxidation of thiols promoted by PhSeZnCl” Tetrahedron Letters. 2012 53, 232-234

International Board


Prof. C. Santi (Chair)

(Univ. of Perugia ITA)



Prof. M.J.Davies 

(Univ. Copenhagen DK)


Prof. J. Drabowicz 

(Univ. of Czestokowa PL)


Prof. M. Iwaoka 

(Univ. of Tokay JP)


Prof. B. Mugesh

(Univ. Bangalore IND)


Prof. R. Radi

(Univ. Montevideo U)


Prof. J.B. Rocha 

(UFSM Santa Maria BR)


Prof. C. Schiesser 

(Selenium Therapeutics AUS)


Prof. E.J. Lenardao

(UFPel Pelotas BR)


Prof. V. Lippolis

(Univ. Cagliari ITA)


Prof. X. Zhao

(Univ. Sun Yat-Sen CHINA)





Dr. Luca Sancineto

Centre of Molecular and Macromolecular Studies in Łódź